dissolution enhancement of glybenclamide by a supercritical fluid-based solvent -antisolvent technique

dissolution enhancement of glibenclamide by solid dispersion: solvent evaporation versus a supercritical fluid-based solvent -antisolvent technique

glibenclamide (glib) is a poorly soluble drug with formulation-dependent bioavailability. therefore, we attempted in this study to improve glib dissolution rate by preparing drug solid dispersions by solvent evaporation (se) and supercritical fluid solvent-antisolvent techniques (scf-sas). a d-optimal mixture design was used to investigate the effects of different ratios of hpmc e5 (50-100%), p...

Dissolution enhancement of glibenclamide by solid dispersion: solvent evaporation versus a supercritical fluid-based solvent -antisolvent technique

Glibenclamide (GLIB) is a poorly soluble drug with formulation-dependent bioavailability. Therefore, we attempted in this study to improve GLIB dissolution rate by preparing drug solid dispersions by solvent evaporation (SE) and supercritical fluid solvent-antisolvent techniques (SCF-SAS). A D-optimal mixture design was used to investigate the effects of different ratios of HPMCE5 (50-100%), PE...

dissolution enhancement of glybenclamide by solid dispersion technique

Supercritical Antisolvent Technique: Production of Nanoparticles

Supercritical antisolvent micronization (SAS) is a versatile technique that allows the obtainment of different morphologies and dimensions of precipitates, but only in some cases nanoparticles were produced. This work is focused on the selection of the SAS operating conditions to obtain this morphology. A series of experiments on several compounds and different solvents at 40 °C and selected pr...

Production of Drug Nanoparticles of Controllable Size Using Supercritical Fluid Antisolvent Technique with Enhanced Mass Transfer

The use of supercritical fluids in the area of material processing and for particle formation has been known for several years now. The advantages of supercritical fluid processing include mild operating temperatures, production of solvent free particles and easy micro encapsulation of particles. One of the attractive methods of particle processing using supercritical fluid is the Supercritical...

Particle Production by Supercritical Antisolvent Processing Techniques

This thesis discusses particle production by supercritical antisolvent processing (SAS) techniques by looking the fundamentals and applications of the method with some case studies. The final aim of this work is however to consider the SAS particle production process feasibility. In the process studied the solid is dissolved in a conventional solvent and the solution is sprayed continuously thr...